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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Per2 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Rattus norvegicus
Tissues/Cell_line rat Müller cell line rMC-1
Methods siRNA transfection, qRT-PCR, Western blot, immunohistochemistry, immunofluorescence
Expression pattern associated
Functional description We observe that siRNA silencing of Bmal and Per2 downregulates Kcnj10 expression, suggesting the direct impact of the clock on Kir4.1 channels.
PubMed ID 28460049
Year 2017
Title Tumor Necrosis Factor Alpha (TNF-α) Disrupts Kir4.1 Channel Expression Resulting in Müller Cell Dysfunction in the Retina.
Drug-related ncRNA NO

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